Chemistry Keeps Us Healthy

Creatine Monohydrate



 In the 1830's, creatine was discovered as a component of meat. In 1842, scientists learned that wild game has a much higher level of creatine in skeletal muscles than farm-raised animals. It was concluded that creatine levels are influenced by exercise. Actually, creatine levels are influenced by diet.
 Creatine is a naturally occurring guanidine-derived compound synthesized from amino acids arginine, glycine, and methionine. More than ninety-five percent of creatine in humans is found in the skeletal muscles. In muscles, creatine functions to re-phosphate ADP (adenosine diphosphate), recreating ATP and allowing for more muscle contration. Creatine has been found to aid in strengh training and athletic activities requiring large bursts of power in relatively short periods of time.
Creatine is not simply a dietary supplement for athletic enhancement. Conclusive research has shown that this compound can also boost memory and intelligence. Creatine has a positive influence on brain function. Tests found that memory and IQ both increased when subjects were taking creatine.
 Another interesting neural effect of creatine is its apparent ability to assist in brain and spinal cord recovery. Continuing tests are showing that creatine helps in the healing process of cortical damage through maintenance of mitochondrial homeostasis. Other studies involving professional athletes have found that those who supplement with creatine have lower instances of concussion. Although the long term side effects of creatine supplementation are not known, it seems to be a promising compound for more than athletic uses.
 

Page by: John Bradley Hyman

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References: 
http://www.healingtherapies.info/creatineNeuroProtection.htm
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12908927&dopt=Abstract
http://news.bbc.co.uk/2/hi/health/3145223.stm
http://nootropics.com/creatine/brainboost.html
http://www.ingenta.com/isis/searching/Expand/ingenta?pub=infobike://mal/jon/2003/00000020/00000007/art00005